The Germanwings plane crashed in northern France, according to authorities.
The French Civil Aviation Authority said the Airbus A320-200 that crashed near Montparnasse, a town in the region of Provence, had an electrical problem, adding that it was a Boeing 777 with a passenger.
The Airbus was heading from Barcelona to Duesseldorf when it crashed in French airspace, the airline said in a statement.
The aircraft was traveling at about 500 kilometers per hour (310 miles per hour) and crashed in a field about 45 kilometers (30 miles) from the French capital, it said.
No injuries were reported.
The crash is the first of several in northern Europe where Germanwings has suffered crashes.
In the United States, a Southwest Airlines jetliner crashed near San Antonio in Texas on March 22, killing all 25 on board.
On Saturday, a United Airlines jet crashed into a cornfield near Fort Worth, Texas, killing three people.
The Boeing 777 crashed into an industrial area in southern Germany near a shipping container in the northern German state of Brandenburg, killing at least 18 people, including the pilot and the captain, authorities said on Saturday.